Faculty Abstracts

2006-2010

Bandara AB, Boyle SM, Rodriguez AC, Martins AM, and Reilly CM. (2007, April) Brucella Melitensis differs from B. Suis in growth and urease activity in vitro and persistence and induction of inflammation in F-344 rats in vivo. Abstract presented Arthritis Foundation.

Cassell M, Strobl JS, Reilly CM, and Lindsay DS. (2006) Efficacy of histone deacetylase inhibitors against Toxoplasma gondii [Abstract]. Southeastern Society of Parasitologists, Abstract#24.

Chen W, Zhu H, Jia Z, Zhou K, Li J, Misra HP, and Li Y. (2009) Aspirin inhibits peroxynitrite-mediated DNA strand breakage and hydroxyl radical formation: implications for cancer intervention. Free Radical Biology and Medicine 47:S167, 2009. (poster, SFRBM, San Francisco).

Chen W, Jia Z, Zhu H, Zhou K, Li Y, and Misra HP. (2009) Ethyl pyruvate inhibits peroxynitrite-induced DNA damage: implication for neuroprotection. Free Radical Biology and Medicine 47:S139, 2009. (poster, SFRBM, San Francisco).

Christofarkas S, Reilly CM, and Rylander MR. (2007, July) Abnormal HSP activation in macrophages in lupus mice interfere with the uptake of apoptotic debris and controlling the inflammatory cascade in SLE. Abstract presented at MAOPs program.

Cohen CA, Karfakis J, Kurnick M, and Rzigalinski BA. (2007) Cerium oxide nanoparticles reduce free radical-mediated toxicity in drosophila melanogaster [Abstract]. Free Radical Biology & Medicine, 43, S68.

Cohen CA, Kurnick M, and Rzigalinski BA. Cerium oxide nanoparticles extend lifespan and protect drosophila melanogaster from paraquat-induced oxidative stress [Abstract]. Soc. Free Radical Biology & Medicine, S78.

Coutermarsh-Ott S, Mustafa A, Holladay S D, Goff M, Witonsky S, Kerr R, Reilly C, Sponenberg P, and Gogal RM Jr. (2008) Developmental TCDD Exposure Induces Autoimmune Lupus in 36-Week-old C57BL/6 Mice. Abstract presented at the 2008 Merck-Merial NIH Veterinary Scholars Symposium Michigan State, Ann Arbor, MI.

Danelisen I, Lou H, Sharma A, Singal PK. (2006) Altered retinoic acid signaling and apoptosis in Adriamycin-induced heart failure [Abstract]. Journal Molecular and Cellular Cardiology, 40:6; 899.

Eden K, Li L, Gan L, Gogal R, Sponenberg P, and Reilly CM. (2008) Anti-inflammatory activity of curcumin in a murine model of autoimmune glomerulonephritis. Abstract presented at the 2008 Merck-Merial NIH Veterinary Scholars Symposium Michigan State, Ann Arbor, MI.

Ehrich M, Fuhrman, K, Wu X, Hinckley J, Were S, Li Y, Jia Z, Van Tassell R, and Kepley C. (2010) Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitro. Toxicological Sciences. 114 (1): 267.

Elswaifi SF, Palmieri JR, and Melissa Jamerson. (2009, November 18-22) The Effects of Salinity And pH on The Survival Of Pathogenic and Non-Pathogenic Acanthamoeba Spp. Poster presented at the American Society of Tropical Medicine and Hygiene, 58th Annual Meeting, Marriott Wardman Park, Washington, DC. Abstract and Poster.

Ferguson E and Hrubec TC. (2009, August 7-8) Evaluation of murine skeletal effects from maternal exposure to tap water. Presented at the National Merck-Merial Veterinary Scholars Symposium. Poster.

Froehlich JP, Mahaney JE, Sumbilla C, and Paolocci N. (2008) Nitroxyl (HNO) activates the cardiac sarcoplasmic reticulum calcium pump in a phospholamban-dependent manner by interacting with cysteine residues in the trans-membrane domain. Poster presented at the Biophysical Society Meeting, Long Beach CA.-

Garland K, Horton G, Olsen J, Roech E, Grisso R, and Wyeth RP. (2006) Design of a human heart transport unit [Abstract]. Virginia Journal of Science 57, 62-3.

Gogal R, Mustafa A, Holliday S, Goff M, Witosnsky S, Kerr R, Reilly CM, Spondnberg D, and Weinstein D. (2008, September) Developmental tetracholodibenxo-ppdioxidn exposure modulates postnatal lupus in SNF1 mice [Abstract]. Biosymposia: Lupus Autoimmunity, La Jolla CA.

Goodwin D, Strobl JS, Hrubec T, Zajac A., and Lindsay, D.S. (2008) Evaluation of the mood stabilizing agent valproic acid as a preventative for toxoplasmosis in mice and activity against tissue cysts in mice [Abstract]. Deans’ Forum on Infectious Disease, Virginia Polytechnic Institute & State University, Blacksburg, VA.

Goodwin DG, Strobl J, Mitchell SM, Zajac AM, and Lindsay DS. (2008) Mood stabilizing and antipsychotic drugs: Demonstration of activity against Toxoplasma gondii in vitro [Abstract]. American Association of Veterinary Pathologists, July 19-21, New Orleans, LA.

Goodwin DG, Strobl J, Mitchell SM, Zajac AM, and Lindsay DS. (2008) The evaluation of mood stabilizing and anti-psychotic drugs for activity against Toxoplasma gondii [Abstract]. Association of Southeastern Biologists, April 16-19, Furman University, South Carolina. Abstract #33.

Gutierrez, JC, Hrubec TC, Prater MR, Smith BJ Freeman LE, and Holladay SD. (2007). Aortic and ventricular dilation in mouse fetuses of diabetic mothers: Improvement with maternal immune stimulation [Abstract]. 47th Annual Teratology Society meeting Pittsburg, PA. Birth Defects Research A, 79: 421.

Gutierrez JC, Hrubec TC, Prater MR, Smith BJ, Freeman LE, and Holladay SD. (2007). Aortic and ventricular dilation and myocardial reduction in gestation day 17 ICR mouse fetuses of diabetic mothers: Improvement of fetal heart development with complete Freund’s adjuvant and interferon gamma [Abstract]. Experimental Biology 2007, Washington DC. The FASEB Journal, 21(6): A974.

Gutierrez JC, Jara KR, Prater MR, and Holladay SD. (2008) Heart changes and apoptosis in fetuses of diabetic mothers: effects of immune stimulation [Abstract]. Presented at the 51st Annual Meeting of the Japan Diabetes Society, Tokyo, Japan.

Gutierrez JC, Prater MR, Hrubec TC, Bahamonde J, Freeman LE, and Holladay SD. (2008). A mouse model of gestational diabetes mellitus using the combination of high fat diet and low-moderate dose of streptozocin [Abstract]. Experimental Biology 2008, San Diego, CA. FASEB Journal, 22:978.12.

Gutierrez JC, Prater MR, Hrubec TC, and Holladay SD. (2008) Maternal hyperglycemic impact on fetal myocardial apoptosis: potential relationship to cardiac defects? [Abstract]. Presented at the 48th Annual Meeting of the Teratology Society, Monterey, CA. Birth Defects Research A,82: 376.

Hisrt S, Seal S, and Reilly CM. (2008) Ce02 inhibits ROS activation in J774 cells [Abstract]. FASEB Experimental Biology Meeting, San Diego, CA.

Hrubec TC, Goodwin D, Lindsay DS, and Holladay SD. (2009, April 18-22) Maternal immune stimulation influences behaviors associated with congenital toxoplasmosis. Presented at EB2009 Annual meeting of the American Association of Anatomists, New Orleans, LA. Poster.

Hrubec TC, Goodwin D, Lindsay DS, and Holladay SD. (2009, June 27-July 1) Alterations in behavior of mice congenitally infected with Toxoplasma. Presented at the 49th Annual meeting of the Teratology Society meeting, Rio Grande, PuertoRico. Poster.

Hrubec TC, Chavan V, Lindsay DS, and Holladay SD. (2008) Fetal outcome of congenital toxoplasmosis is improved with maternal immune stimulation [Abstract]. 48th Annual Teratology Society meeting, Monterey, CA. Birth Defects Research A, 82, 306.

Hrubec TC, Chavan V, Lindsay DS, and Holladay SD. (2008) Maternal immune stimulation improves gestational outcome of congenital toxoplasmosis [Abstract]. Experimental Biology 2008, San Diego, CA. FASEB Journal, 22: 986.5.

Hrubec TC, Li W, Yan M, Ye K, and Holladay SD. (2007) Changes in fetal gene expression from valproic acid and maternal immune stimulation treatments [Abstract]. Invited Speaker at the 47th Annual Teratology Society meeting Pittsburg, PA. Birth Defects Research A, 79: 352.

Hrubec TC, Li W, Yan M, Ye K, and Holladay SD. (2007) Gene expression changes in the developing neural tube from valproic acid and maternal immune stimulation treatments [Abstract]. Experimental Biology 2007, Washington DC. The FASEB Journal, 21(5): A226.

Ikuma Kaoru1, Rzigalinski BA, and Love NG. (2007, March) Predicting the public health impact of oxidative toxins using a bacterial glutathione-gated potassium efflux stress response biosensor [Abstract]. ACS Paper #1060339.

Jia Z, Hallur S, Zhu H, Li Y, and Misra HP. (2007) Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by Alpha-lipoic Acid in human neuroblastoma SH-SY5Y cells: Protection against neurotoxicant-elicited Cytotoxicity [Abstract]. Free Radical Biology & Medicine, 43(S-1):93.

Jia Z and Misra HP. (2006) Reactive oxygen species in pesticides-induced neuronal cells (SH-SY5Y) cytotoxicity in vitro [Abstract]. Toxicological Sciences, 90 (1): 248.

Jia Z and Misra HP. (2006) Exposure to mixture of endosulfan and zineb induces apoptotic cell death in neuronal cells (SH-SY5Y): in Vitro [Abstract]. NeuroToxicology. 27, 924.

Jia Z and Misra HP. (2007) Role of reactive oxygen species, NFkappa B and Casape-3 in pesticide-induced neuronal cell cytotoxicity [Abstract]. Toxicological Sciences, 96(S-1): 43.

Jia Z, Zhu H, Li Y, and Misra HP. (2007) Induction of Endogenous Antioxidants and Phase 2 Enzymes by 3H-1,2-dithiole-3-thione Affords Protection Against Oxidative Injury in Human Neuroblastma Cells [Abstract]. Free Radical Biology & Medicine, 43(S-1):186

Jia Z, Zhu H, Li Y, and Misra HP. (2007) The Role of Glutathione in 3H-1,2-dithiole-3-thione-mediated Cytoprotection Against Acrolein Toxicity in Human Neuroblastoma SH-SY5Y cells [Abstract]. Free Radical Biology & Medicine, 43(S-1):77.

Jia Z, Zhu H, Li Y, and Misra HP. (2010). Potent Inhibition of Peroxynitrite-Induced DNA Strand Breakage and Hydroxyl Radical Formation by the Commonly Used Drug Vehicle DMSO At Extremely Low Concentrations. Toxicological Sciences. 114 (1): 151.

Jia Z, Zhu H, Mahaney, J, Li Y, and Misra HP. (2007) EPR Studies on the Superoxide-scavenging capacity of the nutraceutical resveratrol [Abstract]. Free Radical Biology & Medicine, 43(S-1):15.

Jia Z, Zhu H, Mahaney J, Trush MA, Misra HP, and Li Y. (2007) Generation of Superoxide from Reaction of 3H-1,2-dithiole-3-thione with Thiols: Implications for Dithiolethione Chemo protection [Abstract]. Free Radical Biology & Medicine, 43(S-1):15.

Karfakis J, Liang C, and Rzigalinski BA. (2006) The anti-inflammatory effects of cerium oxide nanoparticles in paraquat-treated microglia [Abstract]. Soc. Free Radical Biology & Medicine.

Lindsay DS, Goodwin D, Mitchell SM, and Strobl J. (2007) Evaluation of the mood stabilizing agent valproic acid as a preventative for Toxoplasmosis in mice[Abstract]. Southeastern Society of Parasitologists, Abstract #29, Belle Baruch Field Station, South Carolina.

Liang C, Oest ME, Jones JC, and Prater MR. Gestational High Saturated Fat Diet Alters C57BL/6 Mouse Skeletal Formation [Abstract]. Presented at the 48th Annual Meeting of the Teratology Society, Monterey, CA.

Liang CL, Oest ME, Jones JC, and Prater MR. (2008) Gestational High Fat Diet Induces Metabolic Dysfunction And Skeletal Malformation In C57BL/6 Mice [Abstract]. Presented at the 2008 EuroTox Meeting, Greece.

Listrani PJ, Radjavi A, Christofakis SC, Ahmed SA, and Reilly CM. (2007, July) 5-aminoimidazole-4-carboxamide ribofuranoside (AICAR) inhibits inflammatory mediator production in vitro in SNF1 Mice. Presented at the Summer Veterinary Research Program, NIH presentation Abstract.

Mahaney JE, Russ J, Dibelka L, Bergman C, Schneider N, Knyushko T, and Bigelow J. (2007) Physical mechanism of Ca2+ transport inhibition by age-based calcium pump nitration. Presented at the Biophysical Society Meeting, Baltimore, MD.

Mallela MK, Gutierrez JC, and Hrubec TC. (2009, April 18-22) A method to quantify apoptosis in mouse embryos using flow cytometry. Presented at EB2009 Annual meeting of the American Association of Anatomists, New Orleans, LA. Poster.

Mallela MK, Gutierrez JC, and Hrubec TC. (2009, June 27-July 1) Flow cytomethric method for quantifying apoptosis in mouse embryos. Presented at the 49th Annual meeting of the Teratology Society meeting, Rio Grande, PuertoRico. Poster.

Mallela MK, Etzkorn FA, Przybyla J, Hrubec TC. (2008) Developmental malformations in mice caused by tap water. Experimental Biology 2008, San Diego, CA. FASEB Journal, 22:984.3.

Mallela MK, Etzkorn FA, Przybyla J, and Hrubec TC. (2008). Municipal tap water as a cause of neural tube defects in mice. 48th Annual Teratology Society meeting, Monterey, CA. Birth Defects Research A, 82, 363.

Mallela MK and Hrubec TC (2007). Anomalous neural tube defects in CD-1 mice [Abstract]. 47th Annual Teratology Society meeting Pittsburg, PA. Birth Defects Research A, 79: 375.

Mallela MK, and Hrubec TC. (2007). Neural tube defects in CD-1 mice [Abstract]. Experimental Biology 2007, Washington DC. The FASEB Journal, 21(5): A227.

Manari A, Mustafa A, Holladay SD, Goff M, Kerr R, Reilly C, Sponenberg P, and Gogal RM Jr. (2008) Exacerbation of lupus in 36-week-old SNF1 Mice prenatally exposed to TCDD [Abstract]. 2008 Merck-Merial NIH Veterinary Scholars Symposium Michigan State, Ann Arbor, MI.

McKay LB, Palmieri JR, and Elswaifi SF. (2009, November 1-3) Examination of Microorganisms In Traditional Cultured Milk Kefir, The Journal of the American Osteopathic Association, 2009's annual conference, New Orleans, LA. Abstract and Poster.

Miles WC, Davis RM, Rzigalinski BA, and Singh N. (2007) Surface chemistry of cerium oxide nanoparticles and its effect on the adsorption of triblock copolymers and potential determining ions [Abstract]. American Adhesion Soc., February.

Nikkhah M, Omotosho A, Strobl JS, and Agah M. (2008) Attachment and growth behavior of metastatic human breast cancer cells in MEMS-based silicon microenvironments [Abstract #0556]. MicroTAS 2008: The 12th International Conference on Miniaturized Systems for Chemistry & Life Sciences, San Diego, CA.

Nikkhah M, Strobl JS, and Agah M. (2007) Geometry-Dependent behavior of fibroblast cells in three-dimensional silicon microstructures [Conference Paper No. 1749]. 29th International Conference of IEEE Engineering in Medicine and Biology Society, Lyon, FRANCE August 23-26.

Nikkhah M, Strobl JS and Agah M. (2007) Fibroblast and cancer cell behaviors in three- dimensional silicon microstructures [Conference Paper No. 0601]. MicroTAS 2007: The Eleventh International Conference on Miniaturized Systems for Chemistry and Life Sciences, Paris, France, October 7-11.

Nikkhah M, Strobl JS, Agah M. (2008) MEMS-Based Three-dimensional microenvironments for cellular analysis [Abstract #OP20]. Solid-State Sensor, Actuator, and Microsystems Workshop, June 8-12, Hilton Head, SC.

Nikkhah M, Strobl JS, and Agah M. (2008) Study the Effect of Anticancer Drugs on Human Breast Cancer Cells using Three Dimensional Silicon Microstructures. Conference Paper in International Mechanical Engineering Congress and Exposition, Oct 31- Nov 6, Boston, MA.

Nikkhah M, Strobl JS, and Agah M. (2008) Development of three-dimensional silicon microenvironments for anticancer drug testing [Abstract]. Virginia Tech Graduate Student Research Symposium Division of Biological, Chemical, and Physical Sciences, Blacksburg, VA. (Awarded 1st Place).

Olgun S, Radjavi A, Santo A, Mishra N, and Reilly CM. (2007,April) Histone diacetylase inhibitor trichostatin-A modulate active disease in MRL/lpr mouse [Abstract]. Arthritis Foundation Research Conference, Stonemountain, GA.

Olgun S, Reilly CM, and Rzigalinski BA. (2006) Cerium oxide nanoparticle decreases disease severity in lupus mice [Abstract]. AAI 2006.

Owens J, Noble T, Coyne M, Gillett L, Griffin C, Anderson F, and Santo A. (2008) Clinical Anatomy: A Case Presentation of Neurofibromatosis Type 2 [Abstract]. 5th Annual Via Research Recognition Day, Blacksburg, VA.

Palmieri JR, Elswaifi SF, and Schwartz J. (2009, November 18-22) Ehrlichiosis: A Case Report From Lynchburg Virginia. Poster presented at the American Society of Tropical Medicine and Hygiene, 58th Annual Meeting, Marriott Wardman Park, Washington, DC. Abstract and Poster.

Palmieri JR and Elswaifi SF. (2009, November 18-22) Low Temperature Induces Trophozoites of Acanthamoeba spp. to Phagocytose Francisella tularensis, Explaining a Possible Mechanism of Survival During Winter. Poster presented at the American Society of Tropical Medicine and Hygiene, 58th Annual Meeting, Marriott Wardman Park, Washington, DC. Abstract and Poster.

Palmieri JR and Elswaifi SF. (2009, November 18-22) The Effect of Low Temperature on Excystment of Pathogenic and Non-Pathogenic Species Acanthamoeba and Their Ability to Undergo Feeding Frenzy and Cannibalism. Oral presentation at the American Society of Tropical Medicine and Hygiene, 58th Annual Meeting, Marriott Wardman Park, Washington, DC. Abstract and Poster.

Palmieri K, Olgun S, and Palmieri JR. (2008) Occipital brain abscess of unknown etiology [Abstract]. Presented at Heartland Home Health Care, Roanoke, VA; and Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA.

Peairs A, Cocco K, and Reilly CM. (2008, September) Activation of AMPK inhibits Inflammation in MRL/lpr Mouse mesangial cells [Abstract].Biosymposia: Lupus Autoimmunity, La Jolla CA.

Prater MR. Heat Illness and the immune system [Abstract]. Presented at the 2008 AOA Research Symposium, Las Vegas, NV.

Reilly CM, Edelstein R, Radjavi A, Nath N, and Giri S. (2008) 5-Amino-4-imidazole carboxamide riboside (AICAR) inhibits inflammatory mediator produciton in mesangial cells from Mrl/Lpr mice [Abstract]. FASEB Experimental Biology Meeting, San Diego, CA.

Reilly CM, Olgun S, Thomas M, Radjavi A, and Mishra N. (2007) Trichostatin-A upregulates Fox-p3 expression in NZB/W mice [Abstract]. Arthritis Foundation Research Conference, Stonemountain, GA.

Singh N, Amateis E, and Rzigalinski BA. (2007) Cerium oxide nanoparticles act as free radical scavengers and block Ab1-42 – induced free radical production [Abstract]. Free Radical Biology & Medicine, 43, S71.

Singh N, Liang C, and Rzigalinski BA. (2006) Antioxidant properties of cerium oxide nanoparticles [Abstract]. Soc. Free Radical Biology & Medicine.

Stiltner B, Goss E, Anderson F, and Lo H. (2008) Clinical anatomy: superior vena cava obstruction. 5th Annual Via Research Recognition Day, Blacksburg, VA

Strobl JS, Nikkhah M, and Agah M (2007) Application of microengineered silicon chips to the study of human metastatic breast cancer and responses to histone deacetylase inhibitors [Abstract#B14]. American Association of Cancer Research: Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications, San Diego, CA, Oct 17-20.

Strobl J, Nagarkatti R, and Rathore D. (2008) Nullscript, an apicomplexan selective inhibitor. Association of Southeastern Biologists, Abstract #27, April 16-19, Furman University, South Carolina.

Strobl J, Ramakrishnan G, Lahlou R, Cassell M, Goodwin D, Reilly C, and Lindsay D. (2006) Histone deacetylases as a new therapeutic target in pathogenic protozoan parasites [Abstract]. Carilion Biomedical Institute Infectious Disease Conference.

Strobl J, Seibert C, Cassell M, Rosypal A, and Lindsay DS. (2007) A new toxoplasmosis drug pharmacophore, 5-nitroso-8-quinolinol (NSC382) Keystone Symposia, Drugs Against Protozoan Parasites, Abstract #219, January 28-February 1, Tahoe City, CA.

Thomas M, Peng S, Radjavi S, and Reilly C M. (2008) TSA inhibits inflammation in increases FOXP3 expression in T regulatory cells in SLE mice [Abstract]. FASEB Experimental Biology Meeting, San Diego, CA.

Toops KA, Hrubec TC, and Holladay SD. (2006) Orofacial clefts induced by diabetes are not affected by maternal immune stimulation [Abstract]. 46th Annual Teratology Society meeting, Tucson, AZ. Birth Defects Research Part A, 73: 310.

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Faculty Abstracts

2006-2010