Regulation of Calcium Transport in Cardiac Muscle:
In this project, the cDNA coding of the Ca-ATPase was modified so that the reactive cysteines were replaced with serines, permitting the site-specific incorporation of precise cysteines that can be used for the covalent attachment of dyes. This research was awarded by the NIH's National Institute on Aging to Pacific Northwest National Laboratory (PNNL). Dr. Mahaney was the subcontractor Principal Investigator. This subcontract was a joint project between VCOM and Virginia Tech, and ended on April 30, 2005.
Signal Processing Methods for Complex Phenotypes:
This project was submitted by Virginia Tech to the National Institute for Biomedical Imaging and Bioengineering, NIH. Dr. Gogal is an Investigator on this proposed research (Principal Investigator: K. Duca). This two-year project was recently awarded, and will begin on June 1, 2005.
Three-Nitrotyrosine in Aging of Skeletal Muscle and Heart:
This research was awarded by the National Institute on Aging (NIH) to Washington State University. Virginia Tech is the subcontracting institution and Dr. Mahaney was the Principal Investigator. This two-year project ended in March 2005, and ran through both VCOM and the Department of Chemistry at Virginia Tech.
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Biomedical Sciences Division: Pending Research Projects
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Dr. James Palmieri
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F. tularensis gene expression and transmission after phagocytosis by Acanthamoeba:
Francisella tularensis, one of the most pathogenic organisms known and the causative agent of tularemia in man, is classified by the CDC as a Category A biological weapons agent. This significance of this study is to understand the relationships between acanthamoebae, as a vector for F. tularensis, and its ability to serve as a means for biological transmission of tularemia through drinking water. This will shed light on how F. tularensis survives and is transmitted in nature and on its potential as a biological weapon to exposed populations through drinking water. Dr. James Palmieri is the principle Investigator on this project and Dr. Tom Inzana, CMMID, Virginia Tech Vet. School, is co-principle investigator. If awarded, this two-year project will be run through both VCOM and Virginia Tech.
Identification Of The Determinants Of Microaerophilic Growth In Human Gastrointestinal Pathogens:
Dr. Richard Seyler submitted this grant to the Goldman Philanthropic Partnership's Charles E. Culpeper Biomedical pilot Initiative. This study proposes to modify and use a transposon-based mutagenesis system to identify genes responsible for the low-oxygen requirement of two gastric pathogens. Identification of the genes involved in microaerophilic growth is an important first step toward the development of new, more specific therapies for the diseases caused by these bacteria. This is a joint project between VCOM and Virginia Tech, and will run for 1 year if awarded.
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Prenatal TCDD and Postnatal Autoimmune Disease:
Dr. Prater and Dr. Gogal are Investigators on a grant submitted by Dr. Steven Holladay at Virginia Tech's College of Veterinary Medicine. This grant was submitted in August 2004 to the NIH. It will run for three years if awarded.
Regulation Of The Cardiac Calcium Pump By Phospholamban:
This project was submitted by the University of Maryland, School of Medicine to the NIH. Dr. James Mahaney is the subcontractor Principal Investigator for Virginia Tech. This grant was submitted in June 2004 and, if awarded, will run for five years.
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Clinical Sciences Division: Current Research & Outreach Projects
Access to Electronic Health Information:
The goal of this project was to increase access to electronic health information and improve health literacy for an underserved region of Appalachia. A partnership, formed between VCOM, the Montgomery-Floyd Regional Libraries, and the Blacksburg Electronic Village, facilitated training in the access of health information via computer for consumers and healthcare providers within Montgomery and Floyd Counties, as well as Southwestern Virginia as a whole. This project was a subcontract under the University of Maryland Health Sciences and Human Services Library's National Network of Libraries of Medicine sponsored by the National Library of Medicine, NIH. Dr. Alfred Pheley is the VCOM Principal Investigator. This project ran for two years and was completed in February 2005.
Addiction Severity Index in Parolees and Probationers, District 28, Radford, Virginia:
The goal of this project is to complete a census of the Addiction Severity Indexes and comment sections collected from District 28 after 2001. This data will be compared to the Addiction Severity Indexes from the Principal Investigator's completed OxyContin® Use, Abuse, and Diversion in Southwest Virginia research study. It is hypothesized that a group of probationers and parolees with drug and alcohol abuse problems will not differ significantly in their scores on the Addiction Severity Index from a group of prisoners incarcerated for OxyContin® possession or diversion. In addition, it is hypothesized that individuals from District 28 who are abusing prescription opioids and benzodiazepines will have a history of drug and alcohol abuse prior to their abuse of prescription drugs. This one-year research project was recently awarded by Purdue Pharma, and Dr. Martha Wunsch is the Principal Investigator.
Appalachian Medical Digital Library Internet Access:
The primary objective of this project is to provide VCOM with equipment, staff, and support to extend current resources to eight community hospitals located throughout underserved regions of Appalachia. This project will create an internet based Digital Library Network (DLN) to enhance library resources and medical information for the region. This 1.5-year project is funded by the NIH's National Library of Medicine, and will be completed in October 2005. Dr. Alfred Pheley is the Principal Investigator of this project.
Redesign and Continuing Education on the Substance Abuse Toolbox:
A Memorandum of Agreement was signed between the Virginia Primary Care Association (VPCA) and VCOM. Dr. Martha Wunsch will redesign the current Substance Abuse Toolbox, a program designed to help health practitioners identify and manage patients in their practices with substance abuse problems. The redesign is important to enhancing the utility of the Toolbox to physicians. The MOA provides funding to VCOM to support Dr. Martha Wunsch's redesign efforts and time associated with four training session conducted in Southwest Virginia.
Smyth County, USA: A Model for Partnering in Health:
This project is a community-based initiative focused on developing new healthcare resources through collaboration between Smyth County and VCOM and expanding existing services by optimizing linkages between healthcare resources that already exist in the County. The specific one-year goals of the project are: (1) to increase access to healthcare for all needy residents of Smyth County, (2) to expand treatment of chronic disease and disability, (3) to enhance resources for stimulating disease prevention and health promotion, (4) to expand assessment of and education about environmental risk factors, and (5) to ensure the long-term sustainability and growth of this collaboration. The Principal Investigator on this project is Dr. Paula Scariati. Award was made in December 2004, and the one-year project will run to January 2006.
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Clinical Sciences Division:
Pending Research & Outreach Projects
Biomedical Basis of Mild Traumatic Brain Injury:
This grant was submitted by Simbex Inc. to the Bioengineering Research Partnerships program at NIH. VCOM is a subcontractor to Simbex and the VCOM Principal Investigator is Dr. P. Gunnar Brolinson. Dr. Pheley is an Investigator on the grant. This proposal was submitted in January 2005, and will run for five years if awarded.
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Dr. P. Gunnar Brolinson
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Dr. Francine Anderson
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Gender Differences in Musculoskeletal Stability:
This grant was submitted by Virginia Tech to the NIH. VCOM is a subcontractor on proposed project, and Dr. Brolinson is the VCOM Principal Investigator and Dr. Francine Anderson is an Investigator. This grant was submitted in May 2004 and, if awarded, will run for five years.
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Health Care Opportunities in Virginia's Appalachian Region:
This grant was submitted by VCOM to the Health Resources and Services Administration (HRSA) on February 22, 2005. Dr. Pheley is the Principal Investigator and Dr. Gogal is the Co-Investigator. If awarded, this project will run for three years.
Opioid Mortality in Southwestern Virginia:
The long-term goal of this research is to characterize a population of deaths in rural southwest Virginia that are the result of misuse and abuse of prescription opioid medications and characterize their lethality in combination with other psychoactive substances. Dr. Martha Wunsch submitted this revision to the National Institute on Drug Abuse, NIH in November 2004. If awarded, this project will run for two years.
Project REMOTE (Rural Enhanced Model for Opioid Treatment Expansion):
This grant was submitted by the Virginia Dept of Mental Health, Mental Retardation, & Substance Abuse Services to the Substance Abuse and Mental Health Services Administration (SAMHSA). Dr. Wunsch is the VCOM Principal Investigator for this project. If awarded, this will be a three-year project.
Teaching Med Students Prevention - Right From the Start:
Dr. Paula Scariati submitted this proposal to the Association of Teachers of Preventive Medicine / CDC in April 2005. If awarded, this three-year project will focus on creating an empirically-validated, gold standard prevention curriculum for medical students. This will be achieved by developing and teaching the foundational tools required to understand Preventive Medicine; developing and teaching methods for applying these tools to master the discipline of disease prevention and health promotion; and modeling, promoting, and supporting a healthy lifestyle. If awarded, Virginia Tech will be a subcontractor to VCOM on this grant.
Telemedicine: Utilization and Barriers in Rural Virginia:
Dr. Rebecca Davis and Dr. Pheley submitted this application to the Virginia State Office of Rural Health in August 2004. This project will run for five months, if awarded, and the requested direct funding is $4,790. This project also has a cost-share portion: VCOM will pay a total of $3,240 to cover the salaries of both Principal Investigators.
The Health Matrix - Engaging Diverse Partners in Community Well Being:
This project will be focused on testing the effectiveness of a community collaborative model to improve health indicators in a rural Appalachian county, Smyth County, Virginia. This project will develop a partnership between a group of community leaders, residents and an academic institution to create a coalition that acts as a single guiding force in the community. Dr. Paula Scariati submitted this proposal to the NIH in May 2005, and if awarded, it will run for two years.
VCOM Community Health Project, Lare Njoro, Kenya:
Dr. Joseph Cacioppo submitted this grant to the Mercy Center Foundation in June 2004. Dr. James Palmieri is an Investigator on this project. If awarded, this project will run for three years.
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Administrative Division:
Current Outreach Projects
A Rural Appalachian Model Medical Education Program:
This grant is helping to establish a rural Appalachian model medical education program and create an academic health center environment in four community hospitals in Southwest Virginia. The program will include medical student training and continuing medical education and physician development through the Buchanan General Hospital, Russell County Medical Center, Norton Community Hospital, and Lee Regional Medical Center. This one-year project was awarded to VCOM by the Commonwealth of Virginia Appalachian Regional Commission in April 2004, and will run to August 2005.
Rural Clinical Training Program:
This grant has recently been awarded via federal appropriation to VCOM and Dr. Tooke-Rawlins (through HRSA). This program will establish new medical training sites in rural areas of Southwestern Virginia as well as West Virginia. This funding is for one year. This project is expected to being in October 2005.
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Other Significant Awards
Robert Wood Johnson Health Policy Fellowship:
This fellowship was awarded to Dr. Pheley in February 2005. Dr. Pheley will participate in health policy processes at the federal level. The experience from this fellowship will provide leadership to improve health, health care, and health policy at all levels. The one-year fellowship begins September 1, 2005. An additional two years may also be awarded for leadership development activities.
Library Training for Hospital Staff:
Ms. Elaine Powers, VCOM Librarian, was recently awarded a training grant from the National Libraries of Medicine. This was awarded in February 2005 for a training session held at VCOM on March 17, 2005. Hospital administrators and physicians from all VCOM-affiliated hospitals were invited to this training session on electronic library databases.
State or Regional Exhibiting Award:
Ms. Elaine Powers was recently awarded this grant to secure exhibit space at the May 2005 VOMA Conference. This award is sponsored by the National Libraries of Medicine Southeastern/Atlantic as part of its outreach program. This program allows network members to exhibit at state or regional meetings of health professionals, library associations, or health consumers.
Internally-Funded Research Projects
Altered Peripheral Cytokine Profiles Associated with Heat Stress in Athletes: Identification of a Circulating Marker for Exercise Induced Endotoxemia:
This project has recently been recommnded for funding by the VCOM Interdisciplinary Review Committee (IRC). Drs. Renee Prater and Gunnar Brolinson are the Principal Investigators. This project aims to define the association between ambient heat stress index, thermal microenvironment of helmet/padding of football equipment, and core body temperature and development of adverse gastrointestinal signs of exercise-induced endotoxemia.
Body Composition Assessment in High School Wrestlers: Relationships of Anthropometrics and Body Hydration:
Drs. Del Bolin and Alfred Pheley (Jesse Donneworth, M.S., and Amy Freel from VT Athletics) received funding for this grant by the VCOM IRC in March 2005. This current research project proposes to validate bio-impedance among euhydrated high school wrestlers.
Brain Injury Evaluation in Real Time of Sports Trauma:
This project is internally-sponsored by both VCOM and Virginia Tech. Dr. Gunnar Brolinson is the Principal Investigator of this project, which is currently in its second year. VCOM allocated Dr. Brolinson funds for purchasing the HITS system. A publication is under review, and the Principal Investigator expects to apply for extramural funding in the near future, based on the data from this project.
Caring for Special People Webpage:
Dr. Ava Stanczak began this VCOM-sponsored project in November 2003. This three-year project will run through December 2006. In this project, Dr. Stanczak has been developing a website for use by parents, caregivers and health care providers that will eventually showcase approximately 900 childhood orphan diseases and their care. One of the goals of the new website is to have medical evidence based information and best practices information all on one site with easy access.
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Experimental Infection of Acanthamoeba Castellanii and A. astronixis with Virulent and Avirulent Strains of Francisella tularensis:
In March 2004, the VCOM IRC awarded funding to Dr. James Palmieri for for this project, with the plans that an application for extramural funding will be forthcoming. Francisella tularensis is the organism that causes cutaneous and pulmonary tularemia in humans. This project will determine the mechanisms on how F. tularensis survives and colonizes and how it maintains itself in its silent cycle in nature.
Measuring Ankle Stability to Predict Ankle Sprains:
Dr. Brolinson began this VCOM-sponsored project in June 2003, and it is currently in its second year. In this project, a device is under development that can quantify ankle stiffness and ankle reflex behavior. This device is being used to measure the ankle stiffness and ankle reflex behavior of members of the Virginia Tech athletics teams during the annual preseason physicals.
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Publications
Abdul M, Santo A, and Hoosein N. (2003). Activity of potassium
channel-blockers in breast cancer. Anticancer Research, 23(4),
3347-3352.
Attur MG, Dave MN, and Amin AR. (2004). Functional genomics approaches
in arthritis. American Journal of Pharmacogenomics, 4(1), 29-43.
Attur MG, Dave MN, Liang M and Kwang P and Amin AR . (In press)
Activation of diverse eicosanoid pathways in human osteoarthritic cartilage: A
lipid and pharmacogenomic analysis. Osteoarthris and Cartilage.
Baker LM, Larsen CT, Sriranganathan N, Jones DE, Johnson MJ, and Gogal RM
Jr. (2004). Effects of energetic compounds on the Northern Bobwhite quail
and biotransformation applications of the intestinal flora. Bulletin of
Environmental Contamination and Toxicology, 72, 1-6.
Bergman J, Robertson J, and Elia G. (2004). Effects of a magnetic field
on urodynamic parameters in women with stress urinary incontinence.
Alternative Therapies in Health and Medicine, 10, 70- 72.
Bolin D and Goforth M. (2004). Electric delivery: Generally well
tolerated by patients, iontophoresis has many uses for the rehab clinician.
Rehab Management, 17, 18-24.
Brolinson PG. (2003). Precompetition manipulation: placebo or
performance enhancer? Clinical Journal of Sport Medicine, 13(2), 69-70.
Brolinson PG. (2004). Predicting the effects of sports-related
concussions in young athletes. Sports Medicine Journal Club Commentary,
Clinical Journal of Sports Medicine, 14(4), 253.
Brolinson PG, Clark N, Juhn M, and Vukovich M. (2004). Nutritional
supplements as ergogenic aids. Patient Care 38, 37-46.
Brolinson PG, Kozar AJ, and Cibor G. (2003). Sacroiliac joint
dysfunction in athletes. Current Sports Medicine Reports, 2(1), 47-56.
Brundage K, Mahaney J, and Barnett J. (2003). The amide class
herbicide 3,4-dichloropropionanilide (DCPA) alters cell membrane fluidity.
Journal of Toxicology and Environmental Health, 66, 2253-2265.
Dace S, Svikis DS, Keyser-Marcus L, Panigrahi B, and Wunsch MJ. (2006).
OxyContin abuse in women: Implications for pregnancy. The Source: The
Newsletter of the National Abandoned Infants Assistance Center.
Danelisen I, Lou H, and Singal PK. (2005). Study of retinoic acid
effects on adriamycin-induced apoptosis in isolated cardiac myocytes.
Experimental and Clinical Cardiology, 10(1), 52.
Das KC and Misra HP. (2003). Prevention of reperfusion lung
injury by lidocaine in a hyperoxic ventilated rat lung model, Journal of
Postgraduate Medicine, 49, 17-20.
Das KC and Misra HP. (2004). Hydroxyl radical scavenging and
singlet oxygen quenching by naturally occurring polyamines. Molecular and
Cellular Biochemistry, 262, 127-133.
Douglas G, Reilly C, Dooley MA, Page G, Cooper G, and Gilkeson G.
(2004). Angiotensin-converting enzyme (insertion/deletion) and endothelial
nitric oxide synthase polymorphisms in patients with systemic lupus
erythematosus. Journal of Rheumatology, 31(9), 1756-62.
Duma SM, Manoogian SJ, Bussone WR, Brolinson PG, Goforth MW,
Donnenwerth JJ, Greenwald RM, Chu JJ, and Crisco JJ. (2005). Analysis of
real-time head accelerations in collegiate football players.
Clinical Journal of Sports Medicine 15, 3-8.
Dr. G. Elia
Elia G, Perez-Reyes N, Rooney M, and Dye TD. (2003). Evaluation of the
estrogen status of the lower urinary tract in women: a prospective study.
Journal of the American Osteopathic Association, 103(8), 384.
Elia G, Scariati PD, and Royal L. (2004). Education on
end-of-life: A community intervention. Journal of the American Osteopathic
Association, 104(9), 392.
Floyd CL, Rzigalinski BA, Sitterding HA, Willoughby KA, and Ellis EF.
(2004). Antagonism of group I metabotropic glutamate receptors and PLC
attenuates increases in inositol trisphosphate and reduces reactive gliosis in
strain-injured astrocytes. Journal of Neurotrauma, 21, 205-216.
Giarelli L, Falconieri G, Zanella M, Cameron JD, and Pheley AM. (2003).
Schabel?s cavernous degeneration: A vascular change of the aging eye.
Archives of Pathology and Laboratory Medicine, 127, 1314-1319.
Glass A and Scariati PD. (2004). Having the talk ? and it?s not about
sex! Journal of the American Medical Women?s Association 59,
278-285.
Gogal RM Jr, Johnson MS, Larsen CT, Duncan RB, Jortner B, Prater
MR, Ward DL, Lee RB, Salice C, and Holladay SD. (2003). Dietary oral
exposure to 1,3,5-trinitro-1,3,5-triazine (RDX) in the Northern Bobwhite
(Colinus virginianus). Environmental Toxicology and Chemistry,
22, 381-387.
Gutierrez JC, Hrubec TC, Prater MR, Smith BJ, Freeman LE and Holladay
SD. (in press). Aortic and ventricular dilation and myocardial reduction in
gestation day 17 ICR mouse fetuses of diabetic mothers. Birth Defects Res A
Clin Mol Teratol.
Guyton K, Zingarelli B, Ashton S, Teti G, Tempel G, Reilly C, Gilkeson
G, Halushka P, and Cook J. (2003). Peroxisome proliferator-activated
receptor-gamma agonists modulate macrophage activation by gram-negative and
gram-positive bacterial stimuli. Shock, 20(1), 56-62.
Hampton CE, Gabler HC, and Rzigalinski BA. (2006). Numerical simulation
of a cellular-level experiment to induce traumatic injury to neurons.
Proceedings of the 43rd Annual Rocky Mountain Bioengineering Symposium.
Holladay SD, Ehich ME, and Gogal RM Jr. (2005). Hormetic dose-response
relationships in immunology: Occurrence, quantitative features of the
dose-response mechanistic foundations and clinical implications. Critical
Reviews in Toxicology, 35, 1-4.
Hrometz SL, Brown AW, Nichols DE, and Sprague JE. (2004).
3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of
hydrogen peroxide in an in vitro model: the role of dopamine, the
serotonin-reuptake transporter, and monoamine oxidase-B. Neuroscience
Letters, 367(1), 56-59.
Hrubec TC, Prater MR, Toops KA, and Holladay SD. (2006).
Reduction in diabetes-induced craniofacial defects by
maternal immune stimulation. Birth Defects Res B Dev Reprod Toxicol,
77(1), 1-9.
Hrubec TC and Smith SA. (2004). Hematology and
blood chemistry reference intervals for yellow perch (Perca flavescens) raised
in recirculation systems. International Journal of Recirculating
Aquaculture, 5, 29-42.
Hrubec TC, Punareewattana K, Prater MR, and Holladay SD. (2005).
Reduction of teratogen induced birth defects in mice: Role of maternal immune
stimulation. Current Topics in Toxicology 1, 1.
Hrubec TC, Ward D, Smith SA, and Robertson JL. (2004).
Age related changes in humoral immune response of hybrid
striped bass (Morone chrysops x Morone saxatilis). Vet Immunol
Immunopathol., 101(1-2), 103-8.
Hrubec TC, Yan M, Ye K, Salafia CM, and Holladay SD. (in press).
Valproic acid induced fetal malformations are reduced by maternal immune
stimulation with granulocyte macrophage colony-stimulating factor or
interferon γ. Submitted to the Anatomical Record Part A, 2006.
Jia Z and Misra HP (2007).
Reactive oxygen species in in vitro pesticide-induced neuronal cell (SH-SY5Y)
cytotoxicity: Role of
NFB and
caspase-3. Free Radical Biology and Medicine, 42, 288-98.
Jia Z and Misra HP (in
press). Developmental exposure to pesticides endosulfan and zineb,
individually or in combination, renders nigrostriatal dopamine system more
susceptible to these environmental chemicals later in life. Journal of
NeuroToxicology.
Jia Z and Misra HP (in
press). Exposure to mixtures of endosulfan and zineb induces apoptotic and
necrotic cell death in SH-SY5Y neuronal cells in vitro. Free Radicals in
Biology and Medicine.
Johnson MS, Gogal RM Jr, and Larsen CT. (2005). Food avoidance behavior
to dietary octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) exposure in
the northern bobwhite (Colinus virginianus). J Toxicol Environ
Health, 68(15), 1349-57.
Johnson MS, Michie MW, Bazae MA, Salice CJ, and Gogal RM Jr. (2005).
Responses of oral 2,4,6-trinitrotoluence (TNT) exposure to the common pidgeon
(Columba livia): A phylogenic and methodological comparison. Int J
Toxicol, 24(4), 221-9.
Jones DE, Gogal RM Jr, Nader PB, and Holladay SD. (2005).
Organochlorine detection in the shed skin of snakes. Ecotoxicol Environ
Saf, 60(3), 282-7.
Karpuzoglu-Sahin E, Gogal RM Jr, Hardy C, Sponenberg P, and Ahmed AS.
(2005). Short-term administration of 17-beta estradiol to outbred male CD-1
mice induces changes in the immune system, but not in reproductive organs.
Immunol Invest, 34(1), 1-26.
Kerger, SR. (2005, September). The most common problem we don?t know
how to treat: Getting to the source of low back pain. AOA Health Watch
Magazine, 4-6.
Kim JS and Mathis JM. (2004).
Percutaneous Vertebroplasty: Rapid Pain
Relief for Vertebral Compression Fractures. J Amer Chiropr Assoc
41(12), 18-21.
Klein AB, Witonsky SG, Ahmed SA, Holladay SD, Gogal RM Jr, Link L, and
Reilly CM. (2006). Impact of different cell isolation techniques on
lymphocyte viability and function. Journal of Immunoassy and
Immunochemistry, 27(1), 61-76.
Knowles S, Hrubec TC, and Smith SA. (in press). Hematology and plasma
chemistry reference intervals for cultural shortnose sturgeon (Acipenser
brevirostrum). Veterinary Clinical Pathology.
Laudermilch CL, Holladay SD, Sponenberg DP, Saunders GK, Ward DL, and
Prater MR. (2005). Placental improvement and reduced distal limb
defects by maternal interferon-gamma injection in methylnitrosourea-exposed
mice. Birth Defects Res A Clin Mol Teratol, 73(9), 597-604.
Leiferman J and Pheley AM. (2006). The effect of mental distress on
women?s preventive health behaviors. American Journal of Health
Promotion, 20(3), 196.
Liang C, Clark A, Hirani A, and Rzigalinski BA. (2004). ATP and
glutamate modulate IL-1 release from microglia. Journal of Neurotrauma,
21, 1272.
Lindsay DS, Kaur T, Mitchell SM, Goodwin D, Strobl J, and Dubey JP.
(2005). Buprenorphine does not affect acute murine toxoplasmosis and is
recommended as an analgesic in Toxoplasma gondii studies in mice. J.
Parasitol, 91(6), 1488-90.
Liu C, Strobl JS, Bane S, Schilling JK, McCracken M, Chatterjee SK,
Rahim-Bata R, and Kingston DGI. (2004). Design, synthesis and bioactivities of
steroid-linked taxol analogs as potential targeted drugs for prostate and
breast cancer. Journal of Natural Products, 67, 152-159.
Mahaney JE, Albers RW, Waggoner JR, Kutchai HC, and Froehlich
JP. (2005). Intermolecular Conformational Coupling and Free Energy Exchange
Enhance the Catalytic Efficiency of Cardiac Muscle SERCA2a following the
Relief of Phospholamban Inhibition. Biochemistry, 44, 7713-7724.
Mahaney JF, Thomas D, and Froehlich JP. (2004). The time-dependent
distribution of phosphorylated intermediates in the native sarcoplasmic
reticulum Ca2+-ATPase from skeletal muscle (SERCA1) is incompatible with a
simple kinetic model. Biochemistry, 43, 4400-4416.
Martirosyan AR, Leonard S, Shi X, Griffith BN, Gannett P, and Strobl
JS. (2006). Actions of a Histone Deacetylase Inhibitor NSC3852
(5-Nitroso-8-quinolinol) Link Reactive Oxygen Species to Cell Differentiation
and Apoptosis in MCF-7 Human Mammary Tumor Cells. J. Pharmacol. Expt. Ther,
317(2), 546-52.
Martirosyan AR, Rahim-Bata R, Freeman AB, Clarke CD, Howard RL, and Strobl
JS. (2004). Differentiation-inducing quinolines as experimental breast
cancer agents in the MCF-7 human breast cancer model. Biochemical
Pharmacology, 68(9), 1729-38.
Masuya M, Drake CJ, Fleming PA, Reilly CM, Zeng H, Hill WD,
Martin-Studdard A, Hess DC, and Ogawa M. (2003). Hematopoietic origin of
glomerular mesangial cells. Blood, 101(6), 2215-2218.
Mathis JM. (2003). Percutaneous vertebroplasty: Complication avoidance
and technique optimization. American Journal of Neuroradiology, 24,
1697-1706.
Mathis JM, Ortiz AO, and Zoarski GH. (2004). Vertebroplasty versus
kyphoplasty: A comparison and contrast. American Journal of Neuroradiology,
25, 840-5.
Mathis JM and Wong W. (2003). Percutaneous vertebroplasty: Technical
considerations. Journal of Vascular and Interventional Radiology,
14(8), 953-60.
McGraw JK, Cardella J, Barr JD, Mathis JM, Sanchez O, Schwartzberg MS,
Swan TS, and Sacks D. (2003). Society of internventional radiology quality
improvement guidelines for percutaneous vertebroplasty. Journal of Vascular
and Interventional Radiology, 14(7), 827-31.
McLoughlin TJ, Snyder AR, Brolinson PG, and Pizza
FX. (2004). Sensory level electrical muscle stimulation: effect on
markers of muscle injury. British Journal of Sports Medicine, 38,
725-9.
Mills EM, Banks ML, Sprague JE, and Finkel T. (2003). Uncoupling the
agony from ecstasy. Nature, 426, 403-404.
Mills EM, Rusyniak DE, and Sprague JE. (2004). The role of the
sympathetic nervous system and uncoupling proteins in the thermogenesis
induced by 3,4-methylenedioxymethamphetamine. Journal of Molecular
Medicine, 82(12), 787-99 (invited review).
Mishra N, Reilly CM, Brown DR, Ruiz P, and Gilkeson GS. (2003). Histone
deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. The
Journal of Clinical Investigation, 111(4), 539-552.
Molano ID, Redmond S, Sekine H, Zhang XK, Reilly C, Hutchison F, Ruiz
P, and Gilkeson GS. (2003). Effect of genetic deficiency of terminal
deoxynucleotidyl transferase on autoantibody production and renal disease in
MRL/lpr mice. Clinical Immunology, 107(3), 186-97.
Dr. S. Olgun
Olgun S, Adeshina F, Choudhury H, and Misra HP. (2003). Pesticide
mixtures increased immunotoxicity in C57BL/6 mice, in vivo. Toxicological
Sciences -The Toxicologist, 72(S-1), 586.
Olgun S, Gogal RM Jr, Adeshina F, Choudhury H, and Misra
HP. (2004). Pesticide mixtures potentiate the toxicity in murine
thymocytes. Toxicology, 196(3), 181-195.
Olgun S and Misra HP (2004). Pesticide mixtures potentiate the
toxicity in murine thymocytes. Toxicology, 196, 181-195.
Olgun S and Misra HP. (2006). Pesticide induced oxidative stress
in thymocytes, Molecular and Cellular Biochemistry (Epub publication,
May 26, 2006).
Olgun S, B Rzigalinski, and CM Reilly. (2006). Cerium
Oxide Nanoparticles Decreases Disease Severity in Lupus Mice. The Journal
of Immunology, C162; 24.
Paolocci N, Katori T, Tocchetti C, Mahaney J, Farrance I, and Froehlich
J. (in press). Nitroxyl anion (HNO/NO-) enhances cardiac muscle SR
Ca-ATPase function by relieving phospholamban inhibition and stimulating
SERCA2a oligomerization. Biophysical Journal.
Pheley A and Dudley G. (2004). Heart attack or heart burn?
American Profile, February.
Pheley AM, Lois H, and Strobl J.
(2006). Interest in research electives among osteopathic medical
students. Journal of the American
Osteopathic Association, 106(11),
667-70.
Pinzone JJ, Stevenson H, Strobl JS, and Berg PE. (2004). Determinants
of estrogen-receptor-alpha expression, Molecular Cell Biology,
24, 4605-12.
Prater MR, Blaylock BL, Gogal RM Jr, and Holladay SD. (2003).
Molecular mechanisms of cis-urocanic acid and permethrin-induced alterations
in cutaneous immunity. Photodermatology, Photoimmunology, and
Photomedicine, 19(6), 287-94.
Prater MR, Gogal RM Jr, Blaylock GL, and Holladay SD. (2003).
Cis-uraocanic acid increases immunotoxicity and lethality of dermally
administered permethrin in C57BL/6N mice. International Journal of
Toxicology, 22(1), 35-42.
Prater MR, Gogal RM Jr, DeFabo EC, Longstreth J, and Holladay
SD. (2003). Immunotoxic effects of cis-urocanic acid exposure in C57BL/6N and
C3H/HeN mice. Photochemistry and Photobiology, 77(4), 383-389.
Prater, M.R., Holladay, S.D., and Blaylock, B.L. (2005). Combined
dermal exposure to permethrin and cis-urocanic acid suppresses the contact
hypersensitivity response in C57BL/6N mice in an additive manner. Journal
of Photochemistry and Photobiology B, 78(1), 29-34.
Prater MR, Johnson VJ, Germolec DR, Luster MI, and Holladay SD. (2006).
Maternal treatment with a high dose of CpG ODN during gestation alters fetal
craniofacial and distal limb development in C57BL/6 mice. Vaccine 24,
263-71.
Prater MR, Laudermilch CL, and Holladay SD. (2006). Does immune
stimulation or antioxidant therapy reduce MNU-induced placental damage via
activation of Jak-STAT and NFkB signaling pathways? Placenta (epub
ahead of print).
Prater MR, Zimmerman KL, Laudermilch CL, and Holladay SD. (2006).
Prebreeding maternal immunostimulation with Freund's complete adjuvant reduces
placental damage and distal limb defects caused by methylnitrosourea. Am J
Reprod Immunity, 55(2), 145-55.
Prater MR, Zimmerman KL, Pinn LC, Keay JM, Laudermilch CL and Holladay
SD. (2006). Role of maternal dietary antioxidant supplementation in murine
placental and fetal limb development. Placenta 27, 502-9.
Prater MR, Zimmerman KL, Ward DL, and Holladay SD. (2004).
Reduced birth defects caused by maternal immune stimulation in
methylnitrosourea-exposed mice: association with placental improvement.
Birth Defects Research Part A: Clinical and Molecular Teratology,
70(11), 862-9.
Pugh TJ and Bolin D. (2004). Overuse injuries in equestrian athletes.
Current Sports Medicine Reports, 3, 297-303.
Punareewattana K, Gogal RM Jr, Sharova LV, Ward DL, and Holladay SD.
(2005). Reduced birth defects caused by maternal immune
stimulation in diabetic ICR mice: lack of correlation with placental gene
expression. Immunol Invest., 34(1), 71-89.
Reilly CM, Mishra N, Miller JM, Joshi D, Ruiz P, Richon VM, and
Gilkeson GS. (2004). Modulation of mesangial cell inflammatory mediator
production and autoimmunity in MRL/lpr mice by suberoylanilide hydroxamic
acid. Journal of Immunology, 173, 4171-8.
Dr. A. Santo
Reilly CM, Olgun S, Goodwin D, Gogal RM Jr, Santo
A, Romesberg J, Ahmed AS, and Gilkeson GS. (2006). Interferon regulatory
factor-1 gene deletion decreases glomerulonephritis in MRL/lpr mice. Eur J
Immunol, 36(5):1296-308.
Rosypal AC, Gogal RM Jr, Zajac AM, Troy GC, and Lindsay DS. (2005).
Flow cytometric analysis of cellular immune responses in dogs experimentally
infected with a North American isolate of Leishmania infantum. Vet
Parasitol, 131(1-2), 45-51.
Rusyniak DE and Sprague JE. (2005). Toxin-induced hyperthermic
syndromes. Med. Clin. N. Am. 89(6), 1277-1296 (invited review).
Rusyniak DE, Scruggs SL, Kamendulis LM, Sprague JE, and Klaunig JE.
(2004). The effects of ecstasy (MDMA) on rat liver bioenergetics. Academic
Emergency Medicine, 11(7), 723-729.
Rzigalinski BA. (2005). Nanoparticles & cell longevity. Tech.
Cancer Res. Treatment 4, 651-660.
Rzigalinski BA, Meehan K, Davis RM, Miles WC, and Cohen CA. (2006).
Radical nanomedicine. Nanomedicine, 1, 399-412.
Scariati PD. (2004). Transitions (editorial). Journal of the
American Medical Women?s Association 59, 234.
Scariati PD, Roberge L, and Dye T. (2006). Beating asthma ? a
community-based education initiative. Journal of the American Osteopathic
Association, 106, 16-22.
Sharova LV, Sharova AA, Sura P, Gogal RM Jr, Smith BJ, and Holladay SD.
(2003). Maternal immune stimulation reduces both placental morphologic damage
and down-regulated placental growth-factor and cell cycle gene expression
caused by urethane: Are these events related to reduced teratogenesis?
International Immunopharmacology, 3(7), 945-955.
Spaeth DG and Pheley AM. (2003). Use of osteopathic
manipulative treatment by Ohio osteopathic physicians in various specialties.
Journal of the American Osteopathic Association, 103(1), 16-26.
Sprague JE, Mallet NM, Rusyniak DE, and Mills E. (2004). UCP3 and
thyroid hormone involvement in methamphetamine-induced hyperthermia.
Biochemical Pharmacology, 68(7), 1339-1343.
Sprague JE, Moze P, Caden D, Rusyniak DE, Holmes C, Goldstein DS, and
Mills EM. (2005). Carvedilol reverses hyperthermia and attenuates
rhabdomyolysis induced by 3,4-methylene-dioxy-meth-amphetamine (MDMA, Ecstasy)
in an animal model. Crit Care Med, 33(6), 1311-6.
Sprague JE and Nichols DE. (2005). Neurotoxicity of MDMA (Ecstasy):
Beyond metabolism. Trends in Pharmacological Sciences, 26(2), 59-60.
Waggoner JR, Huffman J, Froehlich JP, and Mahaney JE. (in press).
Phospholamban inhibits Ca-ATPase conformational changes involving the E2
intermediate. Biochemistry.
Waggoner JR, Huffman J, Griffith B, Jones L, and
Mahaney J. (2004). Improved expression and characterization of
Ca2+-ATPase and phospholamban in High-Five cells. Protein Expression and
Purification, 34, 56-67.
White DC, Greenwood TD, Downey AL, Bloomquist JR, and Wolfe JF. (2004).
Synthesis and anticonvulsant evaluation of some new
2-substituted-3-arylpyridol[2,3-d]pyrimidineones. Bioorganic and Medicinal
Chemistry, 12, 57-1-7.
Witonsky SG, Gogal RM Jr, Buechner-Maxwell V, and Ahmed SA. (2003).
Immunologic analysis of blood samples obtained from horses and stored for
twenty-four hours. American Journal of Veterinary Research, 64(8),
1003-1009.
Witonsky SG, Gogal RM Jr, Duncan RB, and Lindsay DS. (2003).
Immunopathologic effects associated with Sarcocystis neurona-infected
interferfon-gamma knockout mice. Journal of Parasitology, 89(5),
932-940.
Witonsky SG, Gogal RM Jr, Duncan RB, and Lindsay DS. (2003). Protective
Immune response to experimental infection with Sarcocystis neurona in
C57BL/6 mice. Journal of Parasitology, 89(5), 924-931.
Wolfe JW. (2005). Synthesis of 2H-1,2-Benzothiazine 1,1-Dioxides via
hetroannulation reactions of 2-Iodobenzenesulfonamide with ketone enolates
under SRN1 conditions. J Org Chem, 70, 9147-55.
Wunsch MJ. (2006). A chart review comparing paregoric to methadone in
the treatment of neonatal opioid withdrawal. Journal of Addictive Diseases
25(3), 27-33.
Wunsch MJ. (in press). Health literacy: More than reading prescription
labels. Journal of Communication Sciences.
Wunsch MJ, Behonick GS, Massello W. (2006). Opioid mortality in
southwestern Virginia. Journal of Analytical Toxicology, 30(2):159-60.
Wunsch MJ, Knisely J, Cropsey KL, Campbell E. (in press). Impaired
women physicians in four state monitoring programs: Drug and alcohol abuse.
Journal of Addictive Diseases.
Wunsch MJ, Yakamoto K, Goswami A, and Schnoll SH. (in press).
Prescription drug abuse among prisoners in rural Southwestern Virginia.
Journal of Addictive Diseases.
Wunsch MJ, Stanard V, and Schnoll SH. (2003). The treatment of pain in
pregnancy. The Clinical Journal of Pain, 19(3), 148-155.
Xia
S, Villamena FA, Hadad CM, Kuppusamy P, Li Y, Zhu
H, Zweier JL. (2006). Reactivity of dioxygen to ethoxycarbonyl derivatives of
tetrathiatriarylmethyl radicals. J Organic Chem
71,
7268-7279.
Zang LY and Misra HP. (2003). Acetylcholinesterase inhibition by
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride. Molecular and
Cellular Biochemistry, 254, 131-136.
Zhu H, Zhang L, Trush MA, Li
Y. (in press). Upregulation of endogenous glutathione system by
3H-1,2-dithiole-3-thione in pancreatic RINm5F beta-cells as a novel
strategy for protecting against oxidative beta-cell injury. Free Radic
Res.
Abstracts
Cassell M, Strobl JS, Reilly CM, and Lindsay DS. (accepted).
Efficacy of histone deacetylase inhibitors against Toxoplasma gondii
[Abstract]. Southeastern Society of Parasitologists.
Danelisen I, Lou H, Sharma A, Singal P.K. (2006). Altered retinoic acid
signaling and apoptosis in Adriamycin-induced heart failure
[Abstract]. J. Mol.Cell.Cardiol. 40:6; 899.
Ehrich M, Lee YW, Fuhrman K, Parran D, Meldrum B, and Rzigalinski B.
(2005). Transfer and activation of malathion through an in vitro blood-brain
barrier system. Society of Toxicology, Abstract.
Garland K, Horton G, Olsen J, Roech E, Grisso R, and Wyeth RP. (2006).
Design of a human heart transport unit [Abstract]. Virginia Journal of
Science 57, 62-3.
Hrubec TC, Prater MR, Strahl ED, and Holladay SD. (2004).
Maternal immune stimulation affects diabetes induced craniofacial defects
[Abstract]. Experimental Biology, Abstract #8953.
Hrubec TC, Toops K, Yan M, Ye K, and Holladay SD. (2005). Maternal
immune stimulation reduced valproic acid induced neural tube defects
[Abstract]. Birth Defects Research Part A, 73, 310.
Mishra N, Gilkeson, Nghiem, Olgun S, Peng S, and Reilly CM.
(2005). Histone deacetylase inhibitor Tricostatin A upregulates T ell and
modulated autoimmunity in NZB/W F1 mice [Abstract]. Arthritis and
Rheumatism, 52(9), 626.
Rusyniak DE, Scruggs SL, and Sprague JE. (2004). Ecstasy?s effects on
in-vitro and ex-vivo oxidative phophorylation in rodent skeletal muscle
[Abstract]. Society for Academic Emergency Medicine Abstracts, 99.
Strobl J, Martirosyan A, Rahim-Bata R, Freeman A, and Clarke C. (2004).
Experimental breast cancer differentiation agents NSC3852, NSC69603, NSC10010,
and NSC305819. First ISC International Conference on Cancer Therapeutics,
Molecular Targets, Pharmacology and Clinical Applications. Abstract #23.
Strobl J and Rahim-Bata R. (2005). Distinct N-terminal histone H3/H4
modifications during MCF-7 mammary tumor cell differentiation by all-trans
retinoic acid and hydroxychloroquine. Proc. Amer. Assoc. Cancer Res.
Abstract #2745.
Strobl J, Ramakrishnan G, Lahlou R, Cassell M, Goodwin D, Reilly
C, and Lindsay D. (2006). Histone deacetylases as a new therapeutic target
in pathogenic protozoan parasites. Carilion Biomedical Institute Infectious
Disease Conference. Abstract unnumbered.
Wyeth RP and Kennedy RH. (2005). 1
adrenergic receptor mediated aortic contractility differs in female and male
rats but is masked by vascular endothelium [Abstract]. Virginia J Sci,
56, 34-35.
Ziolkowska A, Nghiem A, Snowshite I, Ruiz P, Reilly CM, Gilkeson G, and
Mishra N. (2005). Valproic acid prevents skin disease and attenuated severity
of kidney disease in MRI/lpr lupus like mice [Abstract]. Arthritis and
Rheumatism, 52(9), 626.
Books,
Book Chapters and Reports
Amin AR. (in press). Translational genomics: safeguarding patient
privacy and harnessing the genomic revolution in medicine. University
School of Medicine, Hospital for Joint Diseases: New York.
Amin AR. (2005). Genetic and genomics in Human Osteoarthritis, In
Maritiza Quintero (Ed.), Osteoarticular aging: Osteoarthritis
degeneration.
Gogal RM Jr and Holladay SD. (2005). Developmental Immunotoxicity of
therapeutic immunosuppressive drugs. In SD Holladay (Ed.) Developmental
Immunotoxicology. CRC Press: Boca Raton, FL.
Hrubec TC. (in press). Molecular and protein signals that regulate
normal development and prevent birth defects. In Virginia College of
Osteopathic Medicine?s Research Report.
Hrubec TC, Blaylock BL, and Holladay SD. (2004). Developmental
immunotoxicity of halogenated aromatic hydrocarbons and polycyclic aromatic
hydrocarbons. In. S.D. Holladay (Ed.), Textbook of Developmental
Immunotoxicology. CRC Press: Boca Raton, FL.
Hrubec TC and Holladay SD. (2004). Mycotoxins and other miscellaneous
developmental immunotoxicants. In. SD Holladay (Ed.), Textbook of
Developmental Immunotoxicology. CRC Press: Boca Raton, FL.
Kim J and Mathis M. (2006). Vertebral refracture after percutaneous
vertebroplasty. In JM Mathis, H Deramond and SM Belkoff (Eds.),
Percutaneous Vertebroplasty and Kyphoplasty, 2nd Edition
(277?280). Springer.
Mathis M. (2006). Percutaneous Sacroplasty. In JM Mathis, H Deramond
and SM Belkoff (Eds.), Percutaneous Vertebroplasty and Kyphoplasty,
2nd Edition. Springer.
Mathis JM and Deramond H. (2003). Percutaneous vertebroplasty ? therapy
for painful osteoporotic compression fractures. In Y.H. An (Ed.)
Orthopaedic Issues in Osteoporosis. CRC Press, Boca Raton, FL, pp.
393-402.
Mathis JM, Deramond H, and Belkoff SM. (2006). Percutaneous
Vertebroplasty and Kyphoplasty, 2nd Edition. Springer.
Perry WE. (2004, August). Bath-Highland tobacco use prevention
project for youth: 2003-2004 program evaluation. Edward Via Virginia
College of Osteopathic Medicine, Office of Research Administration:
Blacksburg, VA.
Perry WE. (2005, August). Bath-Highland tobacco use prevention
project for youth: 2004-2005 program evaluation. Edward Via Virginia
College of Osteopathic Medicine, Office of Research Administration:
Blacksburg, VA.
Perry, WE. (2006, October). Special congressional initiatives
program: Rural medical training. Health Resources and Services
Administration, no. D1ARH05296-01-00, Blacksburg, VA: Edward Via Virginia
College of Osteopathic Medicine.
Prater MR. (in press). Cerebrospinal fluid cytology. In USDA Higher
Education Challenge Grant Sponsored Digital Textbook.
Prater MR, Holladay SD, and Blaylock BL. (2004). The mouse as a model
of developmental immunotoxicology. In S.D. Holladay (Ed.) Developmental
Immunotoxicology. CRC Press, Boca Raton, FL, pp. 65-76.
Prater MR and Tvedten H. (2003). Hemostatic abnormalities. In MD
Willard, H Tvedten, & GH Turnwald (Eds.), Small Animal Clinical
Diagnosis by Laboratory Methods, 4th Edition, Elsevier Science.
Rawlins D and Perry E. (2005, August). A rural Appalachian
model medical education program (RAMMEP), final report. Appalachian
Regional Commission, no VA-14820-04, Blacksburg, VA: Edward Via Virginia
College of Osteopathic Medicine.
Rzigalinski BA. (in press). Biological nanoparticles for cell
engineering. In C Kumar (Ed.) Nanotechnologies for Life Sciences, Wiley
& Sons.
Rzigalinski, BA, Danelisen I, Strawn ET, Cohen CA, and Liang C. (in
press). Nanoparticles for cell engineering ? a radical concept. In C Kumar
(Ed.) Nanotechnologies for Life Sciences, Wiley & Sons, press in
March.
National & International Seminars &
Presentations
Anderson F. (2003, September). Bone health and exercise.
Presented at the American Physical Therapy Association Regional Meeting:
Roanoke, VA.
Barter K and Palmieri J. (2006, March, April). Gentamicin and the
symbiotic relationship between francisella and acanthamoeba: The threat of an
epidemiological crisis. Presented at the Joint Meeting of the Southeastern
Society of Parasitologists and the Association of Southeastern Biologists,
Gatlinburg, TN.
Brolinson PG. (2004, February). Pelvic dysfunction in female
athletes. Presented at the American College of Sports Medicine Team
Physician Course: Las Vegas, NV.
Brolinson PG. (2004, February). Sports psychology, what works and
why. Presented at the American College of Sports Medicine Team Physician
Course: Las Vegas, NV.
Brolinson PG. (2004, April). Precompetition manipulation in sports
medicine & Head accelerations and clinical outcomes in college
football players. Papers presented at the Rendezvous 2004 Five Society
International Sports Medicine Meeting: Vancouver BC.
Brolinson PG. (2004, November). Sacroiliac pain syndromes &
Workshop: OMT for sacrolliac pain. Papers presented at the American
Academy of Osteopathy Meeting: San Francisco, CA.
Brolinson PG. (2004, November). Working with the trained athlete ?
pre-competition manipulation & The osteopathic approach to the
athlete: A hands-on approach. Papers presented at the American Osteopathic
Association, 48th Annual AOA Research
Conference: San Francisco, CA.
Danelisen I, Lou H, Sharma A, and Signal PK. (submitted). Altered
retinoic acid signaling and apoptosis in adriamycin induced heart failure.
Submitted to the International Meeting for Heart Research, Toronto, Canada,
June 2006.
Elia G, Bergman J, and Robertson JR. (2003, October). How a magnetic
field affects the pelvic floor muscles of women with stress urinary
incontinence. Paper presented at the 47th Annual Research
Conference, American Osteopathic Association, New Orleans, LA.
Elia G, Perez-Reyes N, Rooney M, and Dye TD. (2003, October).
Evaluation of the estrogen status of the lower urinary tract in women: a
prospective study. Paper presented at the 47th Annual Research
Conference, American Osteopathic Association, New Orleans, LA.
Elia G, Scariati PD, and Royal L. (2004, November). Education
on end-of-life: A community intervention. Paper presented at the
48th Annual Research Conference of the American Osteopathic
Association, San Francisco, CA.
Ellison S, Witonsky SG, Yang J, Gogal RM Jr, Norton H, Duncan RB,
Andrews F, Ward D, and Lindsay DS. (2005, June). Parasitemia to paresis: A
model for S. neurona EPM. Paper presented at the ACVIM 2005 Forum,
Baltimore, MD.
Feanaux JB, Gogal RM Jr, Lindsay D, Hardy C, Ward DL, Saunders G, and
Ahmed, SA. (2005, March). Altered splenocyte functions in fourteen-month
old mice prenatally exposed to Diethylstilbesterol. Presented at the
45th Society of Toxicology International Meeting, New Orleans, LA.
Elia G, Westpfal E, and Horton D. (2003, October). Vesica sling
procedure for stress urinary incontinence: outcome and complications.
Paper presented at the 47th Annual Research Conference, American
Osteopathic Association, New Orleans, LA.
Gogal RM Jr. (2003, June). Immunopathologic
effects associated with sarcocytsis neurona infected interferon-gamma
knock-out mice. Paper presented at the 21st Annual Meeting of the American
College of Veterinary Internal Medicine, Charlotte, NC.
Gogal RM Jr. (2003, March). Immunomodulation by diethylstilbesteroL
is dose and gender linked: Influence on thymic apoptosis and mitogen-induced
proliferation in CD-1 MICE. Paper presented at the 42nd Annual Meeting of
the Society of Toxicology, Salt Lake City, UT.
Gogal RM Jr. (2003, March). Maternal immune stimulation reduces both
placental morphologic damage and down-regulated placental growth-factor and
cell cycle gene expression caused by urethane; are these events related to
reduced teratogenesis? Paper presented at the 42nd Annual Meeting of the
Society of Toxicology, Salt Lake City, UT.
Gogal RM Jr. (2003, June). Protective immune
response to experimental infection with sarcocytsis neurona in C57BL/6
mice. Paper presented at the 21st Annual Meeting of the American College
of Veterinary Internal Medicine, Charlotte, NC.
Gutierrez JC, Hrubec TC, Prater MR, Smith BJ, Freeman LE, and
Holladay SD (2006, August). Cardiovascular changes in 17-day-old fetuses of
type one diabetic mothers using a mouse model [Abstract]. Presented at the
XXVI Congress of the European Association of Veterinary Anatomists, Messina,
Italy.
Hrubec TC, Prater MR, Strahl ED, and Holladay SD. (2004,
April). Maternal immune stimulation affects diabetes induced craniofacial
defects. Invited Poster Discussion, the American Association of Veterinary
Anatomists Annual meeting, Washington, DC.
Hrubec TC, Prater MR, Strahl ED, and Holladay SD. (2004, June).
Diabetes induced craniofacial defects are reduced by maternal immune
stimulation. Paper presented at the Teratology Society Annual Meeting
2004, Vancouver, BC Canada.
Hrubec TC, Prater MR, Troops K and Holladay SD. (2005). Maternal
immune stimulation reduces diabetes induced craniofacial defects
[Abstract]. Presented at the 44th Annual Meeting of the Society of
Toxicology, New Orleans, LA.
Hrubec TC and Smith SA. (2003, April). Toxicity of nitrate and
nitrite to tilapia fish (Abstract #7342). Paper presented at Experimental
Biology 2003, San Diego, CA.
Hrubec TC, Toops KA, and Holladay SD. (2005, April). Reduction in
valproic acid induced neural tube defects with maternal immune stimulation
[Abstract]. Presented at Experimental Biology 2005, San Diego, CA.
Hrubec TC, Toops KA, Yan M, Ye K, and Holladay SD. (2005, June).
Maternal immune stimulation reduces valproic acid induced neural tube
defects. Presented at the Teratology Society 45th Annual
Meeting, Vancouver, BC Canada.
Kerger, SR. (2006, May). What?s new in concussion evaluation.
Presented at the 21st Annual AOASM Conference, Phoenix, AZ.
Kerger, SR, Brolinson PG. (2003, April). Clinical workshop: An
osteopathic approach to the lower extremity in sports. Lecture and lab
presented at the 18th Annual Meeting of the American Osteopathic
Association of Sports Medicine, San Diego, CA.
Kerger, SR, Kerger A, Pelegrin J and Sells L. (2006, May).
Manipulation for small physicians. Presented at the 21st
Annual AOASM Conference, Phoenix, AZ.
Kerr R, Caldwell D, Ameiss K, Hulet M, McElroy A, and Gogal RM Jr.
(2005, June). A preliminary report on the immune changes observed following
inoculation with an Eimeria protein isolate in broiler chickens. Presented
at the 77th Northeastern Conference on Avian Disease, Ithaca, NY.
Laudermilch CL, Holladay SD, Sponenberg DP, Saunders GK,
Ward DL, and Prater MR. (2006, March). Comparison of
birth defect reduction due to non-specific immune stimulation with IFN-gamma
in C57Bl/6N and CD-1 methylnitrosourea-exposed mice.
Poster presentation at the Society of Toxicology Annual
Meeting, San Diego, CA.
Dr. H.P. Misra
Misra HP. (2003, February). Invited Platform Speaker,
29th Annual Conference of Association of Clinical Biochemists of
India, Jaipur, India.
Misra HP. (2003, February). Invited Platform Speaker,
International Society for Free Radical Research: King George Medical College,
Lucknow, India.
Olgun S, Rzigalinski B, and Reilly CM. (2006, April). Cerium Oxide
nanoparticles decrease inflammation in lupus mice. Presented at the
American Association of Immunologists, Boston, MA.
Palmieri J, Barter K, Hricko M, and Pallott M. (2006, March, April).
Low temperature induction of acanthamoebae trophozoites from dormant cysts
influences their ability to phagocytize bacteria. Paper presented at the
2006 Joint Meeting of the Southeastern Society of Parasitologists, and the
Association of Southeastern Biologists, University of Tennessee Knoxville,
Gatlinburg, TN.
Pheley A and Bohland J. (2004, May). Use of medical information
technology in rural hospitals. Oral presentation at the annual conference
of the National Rural Health Association: San Francisco, CA.
Pimentel-Smith GE and Misra HP. (2003, May). The effect of in vivo
exposure of pesticide mixtures on immune function of juvenile mice
(Abstract #E-075). Paper presented at the American Society of Microbiology
Annual Meeting, Washington, DC.
Prater MR. (2003, June). Cases in canine hemostasis. Paper
presented at the American College of Veterinary Internal Medicine 21st Annual
Meeting, Charlotte, NC.
Prater MR. (2003, June). Cases in feline
hemostasis. Paper presented at the American College of Veterinary
Internal Medicine 21st Annual Meeting: Charlotte,
NC.
Prater MR. (2003, June). Focus on platelet
problems: Too few, too many, and too defunct. Paper presented at the
American College of Veterinary Internal Medicine 21st Annual Meeting:
Charlotte, NC.
Prater MR. (2003, June). Miscellaneous cases in
hemostasis including ?toughies.? Paper presented at the American
College of Veterinary Internal Medicine 21st Annual Meeting: Charlotte,
NC.
Prater MR, Pinn LC, Flood AE, Laudermilch CL, Tanner AE, and Holladay
SD. (2006, March). Characterizing the role of maternal dietary antioxidants
in immune regulation and placental and distal limb development in the mouse
model. Poster presentation at the Society of Toxicology Annual Meeting,
San Diego, CA.
Prater MR, Pinn LC, Flood AE, Laudermilch CL, Tanner AE, and Holladay
SD. (2006, July). The role of antioxidant therapy and immunomodulation in
the prevention of birth defects and placental maldevelopment: a mouse model
for preeclampsia? Poster presentation at the American Veterinary Medical
Association, Honolulu, HI.
Prater MR, Pinn L, Keay J, and Holladay SD. (2005, March).
Protection against MNU-induced fetal malformations and placental
maldevelopment with ditary butylated hydroxytoluene supplementation.
Poster presented at the Society of Toxicology Annual Meeting, New Orleans, LA.
Prater MR, Strahl E, and Holladay S. (2004, March). Immune
protection against MNU-induced digital defects. Poster session presented
at the Society of Toxicology Annual Meeting, Baltimore, MD.
Prater MR, Strahl ED, Zimmerman KL, Ward DL, Gogal RM Jr,
and Holladay SD. (2004, June). Reduced birth defects caused by maternal
immune stimulation in methylnitrosourea. Paper presented at Teratology
Society Annual Meeting: Vancouver, BC, Canada.
Reilly CM. (2005, May). Targeting IRF-1 in lupus nephritis.
Presented at the Arthritis Foundation Basic Science Meeting, Atlanta, GA (May
12:1, page 65).
Rzigalinski BA. (2006, April). Cerium oxide nanoparticles increase
lifespan and protect against free-radical mediated toxicity. To be
presented in 2006 for the Federation of American Societies for Experimental
Biology, San Francisco, CA.
Rzigalinski BA. (2006, September). Radical nanomedicine.
Presented at the 8th International Conference on Neuroprotective
Agents,
Mackinac
Island, MI.
Tooke-Rawlins, D. (2006, October). Osteopathic outreach in El
Salvador, Guatemala & the Dominican Republic. Paper presented at the
Annual Osteopathic International Alliance Conference and General Meeting,
Schlangenbad, Germany.
Toops KA, Hrubec TC, and Holladay SD. (2006, April). Diabetes
induced orofacial clefts are not affected by maternal immune stimulation
[Abstract]. Presented at Experimental Biology 2006, San Francisco, CA.
Toops KA, Hrubec TC, and Holladay SD. (2006, June). Orofacial clefts
induced by diabetes are not affected by maternal immune stimulation.
Presented at the Teratology Society 46th Annual Meeting, Tucson,
AZ.
Vemireddi V and Misra HP. (2003, March). The generation of reactive
oxygen species during exposure of pesticide mixtures to immune cells, in
vitro (Abstract 1600). Paper presented at the Society of Toxicology, 42nd
Annual Meeting: Salt Lake City, UT.
Witonsky SG, Gogal RM Jr, Duncan RB, Norton H, Ward D, Suzuki Y, Yang
J, and Lindsay DS. (2005, June). CD8 cells are critical for prevention of
meningo/encephalomyelitis due to Sarcocystis neuroma infection in mice on
C57BL/6 background. Paper presented at the ACVIM 2005 Forum, Baltimore,
MD.
Witonsky SG, Ellison S, Yang J, Gogal RM Jr, Norton H, Andrews F, Ward
D, and Lindsay DS. (2005, June). In vitro alterations in immune function
associated with experimental infection of horses with Sarcocystis neuroma.
Paper presented at the ACVIM 2005 Forum, Baltimore, MD.
Wunsch MJ. (2004, April). Impaired women physicians. Symposium
Presentation at the 35th Annual Conference of the American Society of
Addiction Medicine, Washington, DC.
Wunsch MJ. (2004, April). Pregnancy and substance abuse in 2004:
Methadone and more. Component Session Presentation at the 35th Annual
Conference of the American Society of Addiction Medicine, Washington, DC.
Wunsch MJ. (2004, April). What about the children? Addressing the
needs of children of treated and untreated substance abusers. Component
Session Presentation at the 35th Annual Conference of the American Society of
Addiction Medicine, Washington, DC.
Wunsch MJ. (2006, April). The neurobiology of opiate addiction and
its treatments. Presented at the American Academy of Neurology
58th Annual Meeting, San Diego, CA.
Wunsch MJ. (2006, June). Teaching medical students addiction
medicine: A four year curriculum. Poster presented at the American Academy
of Colleges of Osteopathic Medicine Annual Meeting, Baltimore, MD.
Wunsch, MJ. (accepted for presentation). OxyContin use and misuse
in rural Western Virginia: Identification of the screening instruments, the
prescription misuse index, among substance abuse patients, pain patients, and
criminal justice participants. Abstract to be presented at the
38th Annual Medical Scientific Conference: Miami, FL, April 2007.
Via
Research Recognition Day Presentations
Anderson F, Dudley G, Stanczak A, and DeFeo G.
(2004 September). The anatomy of primary patient care and osteopathic
manipulative medicine: An Innovative Integrated Teaching Approach.
Presented at Via Research Recognition Day, Blacksburg, VA.
Anderson F, Herbert W, and Guigel N. (2004, September).
Biochemical markers of bone turnover in healthy premenopausal women.
Presented at Via Research Recognition Day, Blacksburg, VA.
Anderson F, Long T, Long V, McDuffee E, Ozturk G, Wyeth
RP, and Pitonyak M. (2006, October). The study of adhesive
capabilities of current polymeric materials to embalmed tissue: Preliminary
findings of tensile and mechanical tissue properties. Presented at the
3rd Annual Via Research Recognition Day, Blacksburg, VA.
Barter K and Palmieri J. (2005, October). Gentamicin as a Biocidal
Agent in Controlling Acanthamoeba, A Potential Biological Weapon.
Presented at the 2nd Annual Via Research Recognition Day,
Blacksburg, VA.
Brummer TP, Phillps R, Ahmed SA, and Gogal RM Jr. (2005, October).
Subacute administration of 17-estradiol or 17-ethinyl estradiol does not
alter the reproductive and immune systems of juvenile and aged C57BL/6
mice. Presented at the 2nd Annual Via Research Recognition Day,
Blacksburg, VA.
Garland K, Horton G, Olsen J, Roech E, Grisso R, Wyeth RP. (2005,
September). Design of a human heart transport unit. Presented at the
2nd Annual Via Research Recognition Day, Blacksburg, VA.
Hrubec TC, Prater MR, Strahl ED, and Holladay SD. (2004,
September). Diabetes induced craniofacial defects are reduced by maternal
immune stimulation. Presented at the Via Research Recognition Day,
Blacksburg, VA.
Hrubec TC, Prater MR, Strahl ED, and Holladay SD. (2004,
September). Maternal immune stimulation reduces diabetes induced
craniofacial defects. Presented at the Via Research Recognition Day,
Blacksburg, VA.
Hrubec TC, Toops KA, and Holladay SD. (2006, October). Diabetes
induced changes in palate dimension but not orofacial clefts are improved with
maternal immune stimulation. Presented at the 3rd Annual Via
Research Recognition Day, Blacksburg, VA.
Hrubec TC, Toops KA, Yan M, Ye K, and Holladay SD. (2005, October).
Maternal immune stimulation reduces valproic acid induced neural tube
defects. Presented at the 2nd Annual Via Research Recognition
Day, Blacksburg, VA.
Kerr R, Caldwell D, Ameiss K, Hulet M, McElroy A, and Gogal RM Jr.
(2005, October). In Ovo incubation temperature affects post-natal immune
development in broiler chickens. Presented at the 2nd Annual
Via Research Recognition Day, Blacksburg, VA.
Nichols E and Seyler RW. (2004, September). New in vitro
transposition system for mutagenesis of Helicobacter pylori DNA. Presented
at the Via Research Recognition Day, Blacksburg, VA.
Palmieri JR. (2006, October). Temperature induces acanthamoeba
excystment of cyst stages to actively feeding and reproducing
trophozoites. Presented at the 3rd Annual Via Research
Recognition Day, Blacksburg, VA.
Palmieri JR. (2006, October). Low temperatures induce trophozoites
of acanthamoebae to undergo feeding frenzy and cannibalism and enhance their
ability to phagocytize pathogenic bacteria making them potential
bioweapons. Presented at the 3rd Annual Via Research
Recognition Day, Blacksburg, VA.
Palmieri J and Hricko M. (2005, October). Salinity as a marker for
the differentiation of pathogenic and non-pathogenic Acanthamoeba
isolates. Presented at the 2nd Annual Via Research Recognition
Day, Blacksburg, VA.
Palmieri J and Suliman M. (2005, October). Temperature induced
changes in the feeding form of three species of Acanthamoeba and potential
relationships to Francisella tularensis, the causative agent of tularemia.
Presented at the 2nd Annual Via Research Recognition Day,
Blacksburg, VA.
Prater MR, Pinn LC, Flood AE, Laudermilch CL, Tanner AE, and Holladay
SD. (2005, September). Characterizing the role of maternal dietary
antioxidant supplementation in the protection against teratogen-induced fetal
distal limb maldevelopment in the mouse model. Presented at the
2nd Annual Via Research Recognition Day, Blacksburg, VA.
Prater MR, Pinn LC, Flood AE, Laudermilch CL, Tanner AE, and Holladay
SD. (2006, October). Maternal Exposure to Alkylating Agents Increases
Oxidative Stress, Inflammation, and Fetal Skeletal Defects in a Mouse Model of
Pre-Eclampsia: Role of Dietary Antioxidant Supplementation. Presented at
the 3rd Annual Via Research Recognition Day, Blacksburg, VA.
Prater MR, Pinn LC, Keay J, and Holladay SD. (2004, September).
Protection against MNU-induced fetal malformations and placental
maldevelopment with ditary butylated hydroxytoluene supplementation.
Presented at the Via Research Recognition Day, Blacksburg, VA.
Reilly CM. (2005, October). The histone deacetylase inhibitor
Trichostatin A upregulates regulatory T cells and modulates autoimmunity in
NZB/W F1 mice. Presented at the 2nd Annual Via Research
Recognition Day, Blacksburg, VA.
Rzigalinski BA. (2005, October). Nanomedicine: Applications in aging
and neurodegenerative disorders. Presented at the 2nd Annual
Via Research Recognition Day, Blacksburg, VA.
Dr. R.P. Wyeth
Wyeth RP, Mills EM, Santo A, Sprague JE. (2006, October).
Alpha1 adrenergic responses are gender sensitive in the
hyperthermia and hypertension induced by 3,4-methylenedioxymethamphetamine
(MDMA, Ecstasy). Presented at the 3rd Annual Via Research
Recognition Day, Blacksburg, VA.
Wyeth RP, Kennedy R. (2004, September).
1 adrenergic receptor mediated aortic
contractility differs in female and male rats but is masked by vascular
endothelium. Presented at the Via Research Recognition Day, Blacksburg,
VA.
Wyeth RP, Kennedy R, Liu JS. (2005,
September). A role for chloride Ions in
the response of rat ventricular myocardium to
1-adrenergic
stimulation: Evidence for chloride ion
sensitive and insensitive components. Presented at the 2nd
Annual Via Research Recognition Day, Blacksburg, VA.
State
& Regional Presentations
Barter K and Palmieri J. (2005, November). Gentamicin and the
symbiotic relationship between Francisella and Acanthamoeba: The threat of an
epidemiological crisis. Poster presented at the Virginia Rural Health
Association Annual Fall Conference, Natural Bridge, VA.
Brummer TP, Phillps R, Ahmed SA, and Gogal RM Jr. (2005, May).
Effects of oral 17B-Estradiol and Ethinyl Estradiol subacute exposure on
the immune system of juvenile and aged C57BL/6 mice. Presented at the
17th Annual Research Symposium, Virginia/Maryland Regional College
of Veterinary Medicine, Blacksburg, VA.
Garland K, Horton G, Olsen J, Roech E, Grisso R, Wyeth RP. (2006, May).
A human heart transport unit. Presented at the Virginia Academy of
Science, Annual Scientific Meeting, Blacksburg, VA.
Hrubec TC, Toops KA, and Holladay SD. (2005, May). Maternal immune
stimulation reduces valproic acid induced neural tube defects [Abstract].
Presented at the 17th Annual Research Symposium, VA-MD College of
Veterinary Medicine, VPI&SU, Blacksburg, VA.
Kerger, SR. (2005, March). Family practice osteopathic manipulative
medicine review course. Lecture and workshop presented to third year
osteopathic family practice residents of the Center of Osteopathic Research
and Education (CORE) System, Columbus, OH.
Kerger, SR. (2005, May). Osteopathic physiology in sports.
Lecture given at the 99th Annual Spring Virginia Osteopathic
Medical Association (VOMA) Conference, Hot Springs, VA.
Kerger, SR. (2005, July). On-the-field osteopathy. Workshop at
Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA.
Kerger, SR. (2005, September). Prolotherapy ? then & now.
OOA Fall Conference, Columbus, OH.
Kerger, SR. (2005, October). Introduction to osteopathic history
& principles. Lecture and workshop given at Tazewell County Annual
Conference, Tazewell, VA.
Kerger, SR. (2005, November). An osteopathic approach ? sports
medicine series overview. Lecture and workshop presented to third year
osteopathic family practice residents of the Center of Osteopathic Research
and Education (CORE) System, Columbus, OH.
Kerger, SR. (2006, March). Family practice osteopathic manipulative
medicine board review course. Lecture and workshop presented to third year
osteopathic family practice residents of the Center of Osteopathic Research
and Education (CORE) System, Columbus, OH.
Kerger, SR, Kerger A. (2006, March). Roanoke College ? introduction
to osteopathy. Roanoke College, Salem, VA.
Knight A and Tooke-Rawlins D. (2004, November). Innovative rural
geriatric health initiatives panel. Conducted at the Annual Conference of
the Virginia Rural Health Association, Natural Bridge, VA.
Manoogian SJ, Bussone JD, Stitzel SM, Duma G, Brolinson G, Goforth J,
Donnenworth R, Greenwald J, and Chu T. (2004, April). Measuring in situ
head accelerations and evaluating clinical outcomes in collegiate football
players. Injury Biomechanics Research Workshop.
Palmieri J and Cacioppo J. (2004, May). Bioterrorism and
biopreparedness, an approach for the clinical community and regional emergency
room physicians. Presented at the 98th Annual VOMA Spring
Convention and Scientific Seminar, Hot Springs, VA.
Palmieri J, Cacioppo J, Tooke-Rawlins D, and Willcox
J. (2006, November). Bioterrorism: International problem, rural
solution. Presented at the Virginia Rural Health Association Annual
Conference, Natural Bridge, VA.
Pheley AM. (2004, October). Burden of chronic illness: obesity and
diabetes update 2004. Presented at the Head for the Hills CME Conference,
Southwest Virginia Graduate Medical Education Consortia, Wise, VA.
Pheley AM. (2004, October). Recommendations of the Governor?s rural
OB work group. Presented at the Head for the Hills CME Conference,
Southwest Virginia Graduate Medical Education Consortia, Wise, VA.
Pheley AM. (2005, May). Influenza: thoughts for the future.
Invited presentation at the Spring Conference of the Virginia Osteopathic
Medical Association: The Homestead, VA.
Reilly CM, Gogal RM Jr, Goodwin D, Olgun S, and Ahmed SA. (2005,
May). Targeting interferon in Lupus Nephritis. Presented at the
17th Annual Research Symposium, Virginia/Maryland Regional College
of Veterinary Medicine, Blacksburg, VA.
Rzigalinski BA. (2005). Research in the Rzigalinski lab.
Presented at the Virginia/Maryland Regional College of Veterinary Medicine,
Research Day, Blacksburg, VA.
Rzigalinski BA. (2005, October). Future of brain injury
prediction. Presented at the Short Course in Automobile Safety &
Injury Biomechanics, Center for Injury Biomechanics, Blacksburg, VA.
Rzigalinski BA. (2006, May). Nanomedicine ? new developments in the
room at the bottom. Invited talk, Philadelphia College of Osteopathic
Medicine.
Scariati P. (2004, March). Dr. Atkins versus Dr. Phil ? the science
behind the diets. Presented at the Fourth Annual Four Season?s Women?s
Conference: Fincastle Fincastle, VA.
Scariati P. (2004, November). Nutrition for healthy adolescents and
children. Presented at the annual conference of the Virginia Rural Health
Association, Natural Bridge VA.
Smusz, T. (2006, October). Palliative care:
Challenges for pharmacists. Presented at the Annual Fall Seminar of
Virginia Society of Health-System Pharmacists, Norfolk, VA.
Witonsky SG, Gogal RM Jr, Yang J, and Norton H. (2005, May). Focus
on infectious diseases: EPM and Brucella spp. Presented at the
17th Annual Research Symposium, Virginia/Maryland Regional College
of Veterinary Medicine, Blacksburg, VA.
Wunsch MJ. (2003, May). The treatment of neonatal opioid withdrawal:
A proposed clinical trial of methadone. Paper presented at the
30th Annual Newborn Day, West Virginia University, Charleston
Division: Charleston, WV.
Wunsch MJ. (2005. April). Prescription drug abuse: Science to
practice. Clinical Characteristics of Prescription Opioid Abusing
Patients, NIDA Workshop. American Society of Addiction Medicine Medical
Scientific Conference, Dallas, TX.
Wunsch MJ and Gonzalez ER. (2004, November). Community substance
abuse prevention and intervention programs for the rural health care
provider. Presented at the Annual Conference of the Virginia Rural Health
Association: Natural Bridge, VA.
Wyeth RP, Kennedy R. (2005, May).
1 adrenergic receptor mediated
contractility differs in female and male rats but is masked by vascular
endothelium. Presented at the Virginia Academy of Science, Annual
Scientific Meeting, Harrisonburg, VA.
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